ANTIGENIC CONSTRUCTS

| Written by Kevin Facun

INVENTORS:

Dr. Salvador Eugenio C. Caoili, Dr. Cecile C. Dungog

 

DESCRIPTION

The invention provides for the use of epitope-modifying chemical crosslinking agents to produce surface-binding antigenic constructs for detecting epitope-specific antibodies, said agents abrogating molecular recognition underlying said epitope-specific antibody detection when used in excess.

 

VALUE PROPOSITION

  • Peptide-based materials are biodegradable and environmentally benign.
  • Reduce environmental and health risks of manufacturing and using diagnostic kits.

 

MARKET APPLICATIONS AND COMMERCIAL OPPORTUNITIES

Antibody detection for immunodiagnostic applications depends on immunoassays, which are bioanalytical methods based on the binding of antigens by antibodies. In solid-phase immunoassays that are exemplified by indirect enzyme-linked immunosorbent assay (ELISA), an antigen is directly adsorbed onto a solid-phase surface and then used to capture antibodies that are present in a biological or clinical sample.

In such solid-phase immunoassays, efficient coating of antigen onto the solid-phase surface is necessary. This is a primary concern in developing peptide-based immunoassays wherein short sequence fragments of protein antigens are used to capture antibodies, as a safer alternative to the use of infectious or otherwise biohazardous materials. Furthermore, peptide-based materials are biodegradable and environmentally benign. After use, peptides are easily degraded in the external environment and then are biologically assimilated in nature without complications. The use of synthetic peptide-based constructs aligns with principles of green chemistry, which aims to reduce environmental and health risks posed by chemical agents, through the replacement of hazardous chemical products, synthetic routes, and industrial processes.

 

DEVELOPMENT STATUS

The technology is currently under further research and development

 

IP STATUS

Patent Application Filed

Application No. 1-2019-050254

 

TYPE OF PARTNERSHIP BEING SOUGHT

Licensing. Looking for partners or collaborators with diagnostic kit manufacturers and distributors for commercialization.