National Integrated Research Program on Medicinal Plants
Institute of Herbal Medicine
University of the Philippines Manila
Ampalaya (Momordica charantia) is also known as bitter melon or bitter gourd. In the Philippines, traditional uses include those for cough, colds, asthma, as emetic especially in the newborn, for colic, stomach ache diabetes, anemia, fever, malaria, ringworm, and wounds.
Active components have been identiﬁed in Ampalaya including several cucurbitane triterpenoids. Several mechanisms of action have been proposed such as insulin secretagogue eﬀect, stimulation or peripheral and skeletal muscle glucose and inhibition of intestinal glucose uptake utilization.
- Completed Clinical Trials Phase 1-3
- Decrease in glucose from the 3rd to the 12th week was 8.6-40.8% comparable to Glibenclamide
- HbA1c also decreased from 24.4-40% from the 3rd to the 12th week, also comparable to Glibenclamide
- Correct dose is known as well as onset of action and safety information
MARKET APPLICATION AND COMMERCIAL OPPORTUNITIES
The Philippines is an emerging hotspot for diabetes. There are about 6 million diabetic patients in the country and many more who are yet to be diagnosed. Diabetes is a chronic condition which requires daily maintenance medicines to prevent morbidity, complications and mortality. Poor control of blood sugar leads to end organ damage which may include poor kidney function, loss of sight and amputations.
Ampalaya has been marketed as a food supplement successfully, thus an herbal medicine which has proven eﬃcacy and safety through human trials would be easily accepted.
The technology completed clinical trials phases 1-3 and has shown promising results. It is now available for mass production and is ready for the consumption of the public as medicine.
INTELLECTUAL PROPERTY STATUS
Philippine Patent has been granted and maintained
Strong Know-How protected as a trade secret
TYPE OF COOPERATION
LICENSING with local medicine manufacturers for the mass production and marketing of the final product.